San Francisco 49ers star Deebo Samuel had a blunt reaction when asked about his low numbers to begin this season.

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

When Santa pulls into Herald Square Thursday afternoon, he’s kicking off more than the Christmas season. He’s announcing the unofficial start of NFL playoff-clinching season. The Detroit Lions, ...

What to expect from Sunday Night Football's 49ers vs. Bills matchup. This is one of those games that feels like Buffalo's to ...

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on "Sunday Night Football" in Week 13. The ...

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

Here are the Week 13 games that will impact the 49ers’ playoff chances and which team the 49ers need to win: 49ers need: A ...

The Buffalo Bills might have a chance to clinch the AFC East on Sunday night when they battle the injury-decimated San ...

Here are the full injury reports for the Buffalo Bills and San Francisco 49ers ahead of their Week 13 matchup at Highmark ...

The Buffalo Bills (9-2) are moving on to their their Week 13 contest against the San Francisco 49ers (5-6). Prior to that, ...

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's ...