The Bills and 49ers play Sunday, Dec. 1 at 8:20 p.m. at Highmark Stadium in Orchard Park. The game will be broadcast on local NBC affiliates, including WHEC Channel 10 in Rochester. The game will be ...

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

The Buffalo Bills had a week off to rest after their victory over the Kansas City Chiefs in Week 11. The bye week came at a ...

The Buffalo Bills (9-2) are moving on to their their Week 13 contest against the San Francisco 49ers (5-6). Prior to that, ...

With only a few weeks left on the college football slate, NFL draft season is beginning to hit its stride. Before the San ...

Upon re-joining the Bills, Phillips brought back his long-standing tradition. In the past during practice, Phillips has worn ...

The Green Bay Packers are back in primetime for the first of four consecutive night games, and it's a big one.

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's ...

This is the fifth time the Bills are playing in prime-time this year and they are 3-1, though the loss did come in their only ...

Brock Purdy missed the 49ers' last game against the Packers, but the Bills are preparing as if he's playing on Sunday night.

It’s Week 13 in the NFL, and the Buffalo Bills are preparing to host the San Francisco 49ers on Sunday Night Football at 8:20 ...